Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of the human and mouse unconventional myosin XV genes responsible for hereditary deafness DFNB3 and shaker 2.

Genomics - 1 Nov 1999

Liang Y, Wang A, Belyantseva I A, Anderson D W, Probst F J, Barber T D, Miller W, Touchman J W, Jin L, Sullivan S L, Sellers J R, Camper S A, Lloyd R V, Kachar B, Friedman T B, Fridell R A

Abstract excerpt

Mutations in myosin XV are responsible for congenital profound deafness DFNB3 in humans and deafness and vestibular defects in shaker 2 mice. By combining direct cDNA analyses with a comparison of 95.2 kb of genomic DNA sequence from human chromosome 17p11.2 and 88.4 kb from the homologous region on mouse chromosome 11, we have determined the genomic and mRNA structures of the human (MYO15) and mouse (Myo15)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alternative Splicing
Share to Chromosomes, Human, Pair 17

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cochlea

Share to Deafness

Share to Myosins

Share to Pituitary Gland

Share to Tandem Repeat Sequences

Share to Tissue Distribution

Source

Identifiers

PMID: 10552926
DOI: 10.1006/geno.1999.5976

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of the human and mouse unconventional myosin XV genes responsible for hereditary deafness DFNB3 and shaker 2.PMID 10552926Read ↗

The motor and tail regions of myosin XV are critical for normal structure and function of auditory and vestibular hair cells.Semantic proximity Read ↗

Screening for MYO15A gene mutations in autosomal recessive nonsyndromic, GJB2 negative Iranian deaf population.Semantic proximity Read ↗

MYO15A (DFNB3) mutations in Turkish hearing loss families and functional modeling of a novel motor domain mutation.Semantic proximity Read ↗

Mutational Spectrum of MYO15A and the Molecular Mechanisms of DFNB3 Human Deafness.Semantic proximity Read ↗

Association of unconventional myosin MYO15 mutations with human nonsyndromic deafness DFNB3.Semantic proximity Read ↗

Correction of deafness in shaker-2 mice by an unconventional myosin in a BAC transgene.Semantic proximity Read ↗

Unconventional myosins and the genetics of hearing loss.Semantic proximity Read ↗

Screening of the DFNB3 locus: identification of three novel mutations of MYO15A associated with hearing loss and further suggestion for two distinctive genes on this locus.Semantic proximity Read ↗

Mutations in the first MyTH4 domain of MYO15A are a common cause of DFNB3 hearing loss.Semantic proximity Read ↗

Age-related changes in cochlear gene expression in normal and shaker 2 mice.Semantic proximity Read ↗

Molecular cloning and domain structure of human myosin-VIIa, the gene product defective in Usher syndrome 1B.Semantic proximity Read ↗

Genomic structure of the human unconventional myosin VI gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.