Melatonin‐induced inhibition of proliferation and G₁/S cell cycle transition delay of human choriocarcinoma JAr cells: Possible involvement of MT₂ (MEL_1B) receptor

Abstract excerpt

Melatonin, the pineal neurohormone, is an evolutionarily conserved photoperiodic signaling molecule with diverse functions that include the entrainment of human circadian rhythms. Although evidence supporting a direct inhibitory action of melatonin on human cancer cell proliferation exists in the literature, the molecular and cellular signaling mechanisms involved are largely undefined. In our study, significant...

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