Article
Homotypic and heterotypic antibody responses to a 56-kilodalton protein of Orientia tsutsugamushi.
Infection and immunity - 1 Nov 1999
Choi M S, Seong S Y, Kang J S, Kim Y W, Huh M S, Kim I S
Abstract excerpt
We analyzed homotypic and heterotypic antibody responses to a type-specific antigen (Tsa), a 56-kDa protein of Orientia tsutsugamushi, by using sera from mice immunized with strains Gilliam, Karp, Kato, and Boryong. We generated a series of deletion constructs of the tsa gene and expressed them as MalE fusion proteins. Variable domain I (VD I) showed strong responses to homotypic antibodies. Antigenic domain II...
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