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Article

Microdeletions in FMR2 may be a significant cause of premature ovarian failure.

Journal of medical genetics - 1 Oct 1999

Murray A, Webb J, Dennis N, Conway G, Morton N

Abstract excerpt

Genetic causes of premature ovarian failure (POF) include X chromosome deletions and fragile X (FRAXA) premutations. While screening a cohort of women with POF for FRAXA premutations, a more distal trinucleotide repeat, FRAXE, was also tested. We found an unexpected excess of FRAXE alleles with apparently fewer than 11 repeats in the POF group. However, sequence analysis of these alleles showed that the excess...

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Identifiers

PMID: 10528856
DOI: 10.1136/jmg.36.10.767
PMCID: PMC1734234

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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