Article
Alternative genetic pathways in parathyroid tumorigenesis.
The Journal of clinical endocrinology and metabolism - 1 Oct 1999
Farnebo F, Kytölä S, Teh B T, Dwight T, Wong F K, Höög A, Elvius M, Wassif W S, Thompson N W, Farnebo L O, Sandelin K, Larsson C
Abstract excerpt
In this study 44 parathyroid tumors from 26 sporadic cases, 10 cases previously given irradiation to the neck, and 8 familial cases were screened for sequence copy number alterations by comparative genomic hybridization. In the sporadic adenomas, commonly occurring minimal regions of loss could be defined to chromosome 11 (38%), 15q15-qter (27%), and 1p34-pter (19%), whereas gains preferentially involved...
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