Article
Two polymorphisms in the peroxisome proliferator-activated receptor-gamma gene are associated with severe overweight among obese women.
The Journal of clinical endocrinology and metabolism - 1 Oct 1999
Valve R, Sivenius K, Miettinen R, Pihlajamäki J, Rissanen A, Deeb S S, Auwerx J, Uusitupa M, Laakso M
Abstract excerpt
Peroxisome proliferator-activated receptor-gamma (PPARgamma) is a nuclear receptor that regulates adipocyte differentiation. Variations in the PPARgamma gene may affect the function of the PPARgamma and, therefore, body adipocity. We investigated the frequencies of the Pro12Ala polymorphism in exon B and the silent CAC478CAT polymorphism in exon 6 of the PPARgamma gene and their effects on body weight, body...
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