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Article

Leukemic HRX fusion proteins inhibit GADD34-induced apoptosis and associate with the GADD34 and hSNF5/INI1 proteins.

Molecular and cellular biology - 1 Oct 1999

Adler H T, Chinery R, Wu D Y, Kussick S J, Payne J M, Fornace A J, Tkachuk D C

Abstract excerpt

One of the most common chromosomal abnormalities in acute leukemia is a reciprocal translocation involving the HRX gene (also called MLL, ALL-1, or HTRX) at chromosomal locus 11q23, resulting in the formation of HRX fusion proteins. Using the yeast two-hybrid system and human cell culture coimmunoprecipitation experiments, we show here that HRX proteins interact directly with the GADD34 protein. We have found...

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Identifiers

PMID: 10490642
DOI: 10.1128/MCB.19.10.7050
PMCID: PMC84700

Genes

ELL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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