Article
Differences in allelic distribution of two polymorphisms in the VHL-associated gene CUL2 in pheochromocytoma patients without somatic CUL2 mutations.
The Journal of clinical endocrinology and metabolism - 1 Sept 1999
Duerr E M, Gimm O, Neuberg D S, Kum J B, Clifford S C, Toledo S P, Maher E R, Dahia P L, Eng C
Abstract excerpt
Although the two major familial forms of pheochromocytomas, multiple endocrine neoplasia type 2 and von-Hippel-Lindau disease (VHL), have been associated with mutations of the RET and VHL genes, respectively, the molecular pathogenesis of sporadic pheochromocytomas is largely unknown. Recently, a putative tumor suppressor gene has been identified, CUL2, whose product has been shown to interact with the VHL tumor...
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