Article
Developing dendritic cell polynucleotide vaccination for prostate cancer immunotherapy.
Journal of biotechnology - 20 Aug 1999
Berlyn K A, Ponniah S, Stass S A, Malone J G, Hamlin-Green G, Lim J K, Cottler-Fox M, Tricot G, Alexander R B, Mann D L, Malone R W
Abstract excerpt
Immunotherapy has been successfully used to treat some human malignancies, principally melanoma and renal cell carcinoma. Genetic-based cancer immunotherapies were proposed which prime T lymphocyte recognition of unique neo-antigens arising from specific mutations. Genetic immunization (polynucleotide vaccination, DNA vaccines) is a process whereby gene therapy methods are used to create vaccines and...
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