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Article

Ancestral origin of variation in the triosephosphate isomerase gene promoter.

Human genetics - 1 Jun 1999

Humphries A, Ationu A, Lalloz M R, Layton D M

Abstract excerpt

A high frequency of nucleotide substitutions -5A/G, -8G/A, -24T/G in the triosephosphate isomerase (TPI) gene promoter has been demonstrated in African-Americans. The biological significance of these promoter variants, two of which, -8G/A and -24T/G, occur within regulatory elements essential for transcription, is controversial. The geographical distribution and frequency of allelic variation in the TPI promoter...

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PMID: 10453737
DOI: 10.1007/s004390050992

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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