Article
The relationship of the -5, -8, and -24 variant alleles in African Americans to triosephosphate isomerase (TPI) enzyme activity and to TPI deficiency.
Blood - 15 Oct 1998
Schneider A, Forman L, Westwood B, Yim C, Lin J, Singh S, Beutler E
Abstract excerpt
In 424 African-American and 75 white subjects, we found that the -5 (TPI 592 A-->G), -8 (TPI 589 G-->A), and -24 (TPI 573 T-->G) variants in the triosephosphate isomerase (TPI) gene occurred frequently (41.0%) in the African-American subjects but did not occur in the whites. These data suggest th...
Topics
- Alleles
- Black People
- Gene Frequency
- Haplotypes
- Heterozygote
- Humans
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Polymorphism, Restriction Fragment Length
- Triose-Phosphate Isomerase
- White People
- Black or African American