Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sequencing and genotypic analysis of the triosephosphate isomerase (TPI1) locus in a large sample of long-lived Germans.

BMC genetics - 29 May 2008

Ralser Markus, Nebel Almut, Kleindorp Rabea, Krobitsch Sylvia, Lehrach Hans, Schreiber Stefan, Reinhardt Richard, Timmermann Bernd

Abstract excerpt

BACKGROUND: Triosephosphate isomerase (TPI) is a central and conserved glycolytic enzyme. In humans, TPI is encoded by a single gene on 12p13, and associated with a rare genetic disorder, TPI deficiency. Reduced TPI activity can increase specific oxidant resistances of model organisms and TPI null-alleles have been hypothesized to promote a heterozygote advantage in man. However, comprehensive genetic information...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to Gene Frequency

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Variation

Share to Germany

Share to Isoenzymes

Share to Polymorphism, Single Nucleotide

Share to Sequence Analysis, DNA

Share to Triose-Phosphate Isomerase

Source

Open in PubMed Open full text

Identifiers

PMID: 18510744
DOI: 10.1186/1471-2156-9-38
PMCID: PMC2424074

Genes

TPI1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sequencing and genotypic analysis of the triosephosphate isomerase (TPI1) locus in a large sample of long-lived Germans.PMID 18510744Read ↗

Triose phosphate isomerase deficiency is caused by altered dimerization--not catalytic inactivity--of the mutant enzymes.Semantic proximity Read ↗

Triosephosphate isomerase deficiency: facts and doubts.Semantic proximity Read ↗

Triosephosphate isomerase deficiency: consequences of an inherited mutation at mRNA, protein and metabolic levels.Semantic proximity Read ↗

Evidence for founder effect of the Glu104Asp substitution and identification of new mutations in triosephosphate isomerase deficiency.Semantic proximity Read ↗

Novel human pathological mutations. Gene symbol: TPI1. Disease: triosephosphate isomerase deficiency.Semantic proximity Read ↗

Molecular analysis of a series of alleles in humans with reduced activity at the triosephosphate isomerase locus.Semantic proximity Read ↗

Triose phosphate isomerase deficiency associated with two novel mutations in TPI gene.Semantic proximity Read ↗

Identical germ-line mutations in the triosephosphate isomerase alleles of two brothers are associated with distinct clinical phenotypes.Semantic proximity Read ↗

Triosephosphate isomerase deficiency: historical perspectives and molecular aspects.Semantic proximity Read ↗

Evidence of a triosephosphate isomerase non-catalytic function crucial to behavior and longevity.Semantic proximity Read ↗

A synonymous mutation of ancient origin in the glucose-6-phosphate dehydrogenase gene and assessment of haplotypes.Semantic proximity Read ↗

Human triosephosphate isomerase deficiency resulting from mutation of Phe-240.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.