Article
A yolk protein mutant leads to defects in the secretion machinery of Drosophila melanogaster.
Tissue & cell - 1 Apr 1999
Butterworth F M, Burde V S, Mauchline D, Bownes M
Abstract excerpt
The three yolk proteins of Drosophila melanogaster are synthesized in the fat body and ovarian follicle cells. A mutation in yolk protein 3, YP3S1, has been described in which the leader sequence is not cleaved from the protein. We describe here ultrastructural and molecular studies on the YP3S1 mutant and show that the mutant protein enters the secretory pathway and forms precipitates, often as electron dense...
Topics
- Animals
- Drosophila Proteins
- Drosophila melanogaster
- Egg Proteins
- Fat Body
- Female
- Mutation
- Oocytes
- Ovary
- Oviposition
- Ovum