Article
Differences in the gyral pattern distinguish chromosome 17-linked and X-linked lissencephaly.
Neurology - 22 Jul 1999
Dobyns W B, Truwit C L, Ross M E, Matsumoto N, Pilz D T, Ledbetter D H, Gleeson J G, Walsh C A, Barkovich A J
Abstract excerpt
BACKGROUND: Classical lissencephaly or "smooth brain" is a human brain malformation that consists of diffuse agyria and pachygyria. Two genes associated with classical lissencephaly have recently been cloned-LIS1 from chromosome 17p13.3 and XLIS (also called DCX) from Xq22.3-q23. OBJECTIVE: We performed genotype-phenotype analysis in children with lissencephaly associated with mutations of different genes....
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