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Article

Tissue-specific methylation differences in a fragile X premutation carrier.

Clinical genetics - 1 May 1999

Tassone F, Longshore J, Zunich J, Steinbach P, Salat U, Taylor A K

Abstract excerpt

Methylation of a premutation was found in a small percentage of blood cells in a male premutation carrier for the FMR1 mutation. To investigate the inter-tissue heterogeneity and possible clinical implications of this finding, fibroblast cells from the subject were also studied. Although the premutation size was found to be the same in leukocytes and fibroblasts, the methylation pattern was different. In cultured...

Topics

DNA
DNA Methylation
Female
Fragile X Mental Retardation Protein
Fragile X Syndrome
Genetic Carrier Screening
Humans
Immunohistochemistry
Male
Mutation
Nerve Tissue Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA-Binding Proteins

Source

Identifiers

PMID: 10422805
DOI: 10.1034/j.1399-0004.1999.550508.x

Genes

FMR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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Tissue-specific methylation differences in a fragile X premutation carrier.PMID 10422805Read ↗

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