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Article

The trefoil peptide TFF1 inhibits the growth of the human gastric adenocarcinoma cell line AGS

1 Jul 1999

Abstract excerpt

TFF1 is a 60-amino acid peptide produced in normal gastric mucosa which forms dimers spontaneously. Tumours of patients with gastric cancer usually have reduced TFF1 levels and disruption of the TFF1 gene causes animals to develop gastric adenomas and carcinomas. The effect of normal sequence human recombinant TFF1 and an analogue (Cys(58)-->Ser(58)), which is unable to dimerize, on the proliferation and...

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Identifiers

PMID: 10419601
DOI: 10.1002/(sici)1096-9896(199907)188:3<312::aid-path360>3.0.co;2-p

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