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Article

Derepressed hyphal growth and reduced virulence in a VH1 family-related protein phosphatase mutant of the human pathogen Candida albicans.

Molecular biology of the cell - 1 Dec 1997

Csank C, Makris C, Meloche S, Schröppel K, Röllinghoff M, Dignard D, Thomas D Y, Whiteway M

Abstract excerpt

Mitogen-activated protein (MAP) kinases are pivotal components of eukaryotic signaling cascades. Phosphorylation of tyrosine and threonine residues activates MAP kinases, but either dual-specificity or monospecificity phosphatases can inactivate them. The Candida albicans CPP1 gene, a structural member of the VH1 family of dual- specificity phosphatases, was previously cloned by its ability to block the pheromone...

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Identifiers

PMID: 9398674
DOI: 10.1091/mbc.8.12.2539
PMCID: PMC25726

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