Article
Derepressed hyphal growth and reduced virulence in a VH1 family-related protein phosphatase mutant of the human pathogen Candida albicans.
Molecular biology of the cell - 1 Dec 1997
Csank C, Makris C, Meloche S, Schröppel K, Röllinghoff M, Dignard D, Thomas D Y, Whiteway M
Abstract excerpt
Mitogen-activated protein (MAP) kinases are pivotal components of eukaryotic signaling cascades. Phosphorylation of tyrosine and threonine residues activates MAP kinases, but either dual-specificity or monospecificity phosphatases can inactivate them. The Candida albicans CPP1 gene, a structural...
Topics
- Amino Acid Sequence
- Animals
- Binding Sites
- Candida albicans
- Candidiasis
- Cell Division
- Cell Size
- Dual-Specificity Phosphatases
- Female
- Fungal Proteins
- Gene Deletion
- Kidney
- Mice
- Mice, Inbred BALB C
- Mitogen-Activated Protein Kinase 3