Article
Evidence that HLA-B*2706 is not protective against spondyloarthropathy.
The Journal of rheumatology - 1 Jul 1999
Sudarsono D, Hadi S, Mardjuadi A, Nasution A R, Dekker-Saeys A J, Breur-Vriesendorp B S, Lardy N M, Feltkamp T E
Abstract excerpt
OBJECTIVE: Studies in Southeast Asia showed that HLA-B*2704 is positively associated with spondyloarthropathy (SpA), while B*2706 does not occur in such patients. In view of the absence of an association between B*2706 and SpA it was suggested that B*2706 protects against the disease, while it is supposed that B*2704 presents pathogenetic peptides. We studied families in which both B*2704 and B*2706 occurred to...
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