Article
Biocompatibility of a fish scale-derived artificial cornea: Cytotoxicity, cellular adhesion and phenotype, and in vivo immunogenicity.
Biomaterials - 1 Mar 2016
van Essen T H, van Zijl L, Possemiers T, Mulder A A, Zwart S J, Chou C-H, Lin C C, Lai H J, Luyten G P M, Tassignon M J, Zakaria N, El Ghalbzouri A, Jager M J
Abstract excerpt
PURPOSE: To determine whether a fish scale-derived collagen matrix (FSCM) meets the basic criteria to serve as an artificial cornea, as determined with in vitro and in vivo tests. METHODS: Primary corneal epithelial and stromal cells were obtained from human donor corneas and used to examine the (in)direct cytotoxicity effects of the scaffold. Cytotoxicity was assessed by an MTT assay, while cellular...
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