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Article

The gene mutated in bare patches and striated mice encodes a novel 3beta-hydroxysteroid dehydrogenase.

Nature genetics - 1 Jun 1999

Liu X Y, Dangel A W, Kelley R I, Zhao W, Denny P, Botcherby M, Cattanach B, Peters J, Hunsicker P R, Mallon A M, Strivens M A, Bate R, Miller W, Rhodes M, Brown S D, Herman G E

Abstract excerpt

X-linked dominant disorders that are exclusively lethal prenatally in hemizygous males have been described in human and mouse. None of the genes responsible has been isolated in either species. The bare patches (Bpa) and striated (Str) mouse mutations were originally identified in female offspring of X-irradiated males. Subsequently, additional independent alleles were described. We have previously mapped these...

Topics

3-Hydroxysteroid Dehydrogenases
Alleles
Amino Acid Sequence
Animals
Chromosome Mapping
Crosses, Genetic
Exons
Eye Abnormalities
Female
Fibroblasts

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Male

Mice

Mice, Inbred C3H

Mice, Mutant Strains

Molecular Sequence Data

Mutation

Point Mutation

Source

Identifiers

PMID: 10369263
DOI: 10.1038/9700

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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The gene mutated in bare patches and striated mice encodes a novel 3beta-hydroxysteroid dehydrogenase.PMID 10369263Read ↗

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