Article
Dedifferentiation derived cells exhibit phenotypic and functional characteristics of epidermal stem cells.
Journal of cellular and molecular medicine - 1 May 2010
Zhang Cuiping, Fu Xiaobing, Chen Peng, Bao Xiaoxia, Li Fu, Sun Xiaoyan, Lei Yonghong, Cai Sa, Sun Tongzhu, Sheng Zhiyong
Abstract excerpt
Differentiated epidermal cells can dedifferentiate into stem cells or stem cell-like cells in vivo. In this study, we report the isolation and characterization of dedifferentiation-derived cells. Epidermal sheets eliminated of basal stem cells were transplanted onto the skin wounds in 47 nude athymic (BALB/c-nu/nu) mice. After 5 days, cells negative for CK10 but positive for CK19 and beta1-integrin emerged at the...
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