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VacA from <i>Helicobacter pylori</i>: a hexameric chloride channel

30 Apr 1999

Abstract excerpt

VacA is a unique protein toxin secreted by the human pathogen Helicobacter pylori. At a neutral pH, the cytotoxin self-associates into predominantly dodecameric complexes. In this report, we show that at an acidic pH, VacA forms anion selective channels in planar phospholipid bilayers. Similar to several other chloride channels, the VacA channel exhibits a moderate selectivity for anions over cations (P(Cl):P(Na)...

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PMID: 10350065
DOI: 10.1016/s0014-5793(99)00474-3

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