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Article

FMRP expression as a potential prognostic indicator in fragile X syndrome.

American journal of medical genetics - 28 May 1999

Tassone F, Hagerman R J, Iklé D N, Dyer P N, Lampe M, Willemsen R, Oostra B A, Taylor A K

Abstract excerpt

Absence or deficit of FMR1 protein (FMRP) resulting from methylation of full mutation genes is the fundamental defect in fragile X syndrome. We used FMRP immunocytochemistry and detailed phenotypic assessment to investigate the relationship between degree of FMRP expression and the broad clinical spectrum of impairment in 80 individuals affected with fragile X syndrome. FMRP expression correlated with IQ in...

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Share to Fragile X Mental Retardation Protein
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10331602

Genes

FMR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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FMRP expression as a potential prognostic indicator in fragile X syndrome.PMID 10331602Read ↗

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Molecular-clinical correlations in males with an expanded FMR1 mutation.Semantic proximity Read ↗

Evidence that methylation of the FMR-I locus is responsible for variable phenotypic expression of the fragile X syndrome.Semantic proximity Read ↗

A near normal distribution of IQ in Fragile X Syndrome.Semantic proximity Read ↗

Fragile X syndrome in a normal IQ male with learning and emotional problems.Semantic proximity Read ↗

Mosaicism for a full mutation, premutation, and deletion of the CGG repeats results in 22% FMRP and elevated FMR1 mRNA levels in a high-functioning fragile X male.Semantic proximity Read ↗

High functioning fragile X males: demonstration of an unmethylated fully expanded FMR-1 mutation associated with protein expression.Semantic proximity Read ↗

Molecular predictors of cognitive involvement in female carriers of fragile X syndrome.Semantic proximity Read ↗

Molecular-intelligence correlations in young fragile X males with a mild CGG repeat expansion in the FMR1 gene.Semantic proximity Read ↗

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