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Article

The C677T MTHFR gene mutation is not predictive of risk for recurrent fetal loss.

British journal of haematology - 1 Apr 1999

Holmes Z R, Regan L, Chilcott I, Cohen H

Abstract excerpt

We have investigated the potency of the C677T mutation in the methylene tetrahydrofolate reductase (MTHFR) gene as a genetic risk factor in women with a history of early (</=12 weeks gestation) and/or late (>12 weeks gestation) recurrent miscarriage (three or more consecutive pregnancy losses). Fifty-seven of the total 173 (32. 9%) patients were heterozygous for the MTHFR mutation, 14/173 (8.1%) were homozygous...

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Source

Identifiers

PMID: 10233370

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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The C677T MTHFR gene mutation is not predictive of risk for recurrent fetal loss.PMID 10233370Read ↗

The C677T polymorphism of the methylenetetrahydrofolate reductase gene and idiopathic recurrent miscarriage.Semantic proximity Read ↗

Factor V Leiden and prothrombin G20210A mutations, but not methylenetetrahydrofolate reductase C677T, are associated with recurrent miscarriagesSemantic proximity Read ↗

Mutations in the factor V, prothrombin and MTHFR genes are not risk factors for recurrent fetal loss.Semantic proximity Read ↗

G20210A prothrombin gene mutation: prevalence in a recurrent miscarriage population.Semantic proximity Read ↗

Maternal methylenetetrahydrofolate reductase (MTHFR) A1298C polymorphism: implications in preventing recurrent pregnancy loss.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase C677T polymorphism and the risk of unexplained recurrent pregnancy loss: a meta-analysis.Semantic proximity Read ↗

Effects of inherited thrombophilia in women with recurrent pregnancy loss.Semantic proximity Read ↗

Polymorphism for mutation of cytosine to thymine at location 677 in the methylenetetrahydrofolate reductase gene is associated with recurrent early fetal loss.Semantic proximity Read ↗

Prevalence of genetic markers for thrombophilia in recurrent pregnancy loss.Semantic proximity Read ↗

No association of C677T methylenetetrahydrofolate reductase and an endothelial nitric oxide synthase polymorphism with recurrent pregnancy loss.Semantic proximity Read ↗

[A weak association of 677 C>T polymorphism in MTHFR with recurrent embryonic loss].Semantic proximity Read ↗

[Genetic variant C677T in the MTHFR in women with recurrent early fetal loss].Semantic proximity Read ↗

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