Article
Altered temperature induction sensitivity of the lambda pR/cI857 system for controlled gene E expression in Escherichia coli.
FEMS microbiology letters - 15 Apr 1999
Jechlinger W, Szostak M P, Witte A, Lubitz W
Abstract excerpt
Cell lysis of Gram-negative bacteria can be efficiently achieved by expression of the cloned lysis gene E of bacteriophage PhiX174. Gene E expression is tightly controlled by the rightward lambda pR promoter and the temperature-sensitive repressor cI857 on lysis plasmid pAW12. The resulting empty bacterial cell envelopes, called bacterial ghosts, are currently under investigation as candidate vaccines. Expression...
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