Impairment of Plasmodium falciparum growth in thalassemic red blood cells: further evidence by using biotin labeling and flow cytometry.

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Article

Impairment of Plasmodium falciparum growth in thalassemic red blood cells: further evidence by using biotin labeling and flow cytometry.

Blood - 1 May 1999

Pattanapanyasat K, Yongvanitchit K, Tongtawe P, Tachavanich K, Wanachiwanawin W, Fucharoen S, Walsh D S

Abstract excerpt

Certain red blood cell (RBC) disorders, including thalassemia, have been associated with an innate protection against malaria infection. However, many in vitro correlative studies have been inconclusive. To better understand the relationship between human RBCs with thalassemia hemoglobinopathies and susceptibility to in vitro infection, we used an in vitro coculture system that involved biotin labeling and flow...

Topics

Animals
Biotin
Erythrocytes
Flow Cytometry
Genetic Predisposition to Disease
Heterozygote
Homozygote
Humans
In Vitro Techniques
Malaria, Falciparum
Plasmodium falciparum
Reproduction
Splenectomy
alpha-Thalassemia
beta-Thalassemia

Source

Open in PubMed

Identifiers

PMID: 10216109

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