Article
Differences between hereditary and sporadic ovarian cancer.
European journal of obstetrics, gynecology, and reproductive biology - 1 Feb 1999
Zweemer R P, Verheijen R H, Menko F H, Gille J J, van Diest P J, Coebergh J W, Shaw P A, Jacobs I J, Kenemans P
Abstract excerpt
Approximately 5% of ovarian cancer cases can be attributed to an autosomal dominant inheritance factor. The majority of these cases are due to germline mutations in the BRCA1 or BRCA2 tumoursupressor genes. Patients with hereditary disease do not exhibit pathognomonic features that would allow distinction from non-hereditary (sporadic) cases of ovarian cancer. Our studies are aimed at identifying clinical,...
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