Article
Hereditary and sporadic ovarian cancer: genetic testing and clinical implications (review).
International journal of oncology - 1 May 1998
Angioli R, Estape R, Mason M, Penalver M
Abstract excerpt
The two most common forms of hereditary ovarian cancer are: the breast ovarian cancer syndrome, and ovarian cancer associated with HNPCC (hereditary nonpolyposis colorectal cancer) syndrome. Studies have shown that these diseases may be associated with mutations in a number of tumor suppressor genes, mainly BRCA1 and BRCA2. Malfunction of the protein products of these genes have also been found to be involved in...
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