Article
Tau gene mutation in familial progressive subcortical gliosis.
Nature medicine - 1 Apr 1999
Goedert M, Spillantini M G, Crowther R A, Chen S G, Parchi P, Tabaton M, Lanska D J, Markesbery W R, Wilhelmsen K C, Dickson D W, Petersen R B, Gambetti P
Abstract excerpt
Familial forms of frontotemporal dementias are associated with mutations in the tau gene. A kindred affected by progressive subcortical gliosis (PSG), a rare form of presenile dementia, has genetic linkage to chromosome 17q21-22. This kindred (PSG-1) is included in the 'frontotemporal dementias and Parkinsonism linked to chromosome 17' group along with kindreds affected by apparently different forms of atypical...
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