Article
Protective role of beta-chemokines associated with HIV-specific Th responses against perinatal HIV transmission.
Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 1999
Wasik T J, Bratosiewicz J, Wierzbicki A, Whiteman V E, Rutstein R R, Starr S E, Douglas S D, Kaufman D, Sison A V, Polansky M, Lischner H W, Kozbor D
Abstract excerpt
To examine the protective role of cellular immunity in the vertical transmission of HIV, we analyzed HIV-specific IL-2 and CTL responses, as well as beta-chemokine expression in HIV-infected and uninfected infants of HIV+ mothers. Our results showed that HIV envelope (env) peptide-specific IL-2 responses associated with beta-chemokine production were detectable at birth in the majority of uninfected infants of...
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