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Article

The RNA-Binding Properties of SMN: Deletion Analysis of the Zebrafish Orthologue Defines Domains Conserved in Evolution

1 May 1999

Abstract excerpt

Spinal muscular atrophy (SMA) is a common autosomal recessive disorder that results in the degeneration of spinal motor neurons. SMA is caused by alterations of the survival motor neuron ( SMN ) gene which encodes a novel protein of hitherto unclear function. The SMN protein associates with ribonucleoprotein particles involved in RNA processing and exhibits an RNA-binding capacity. We have isolated the zebrafish...

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PMID: 10196366
DOI: 10.1093/hmg/8.5.775

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The RNA-Binding Properties of SMN: Deletion Analysis of the Zebrafish Orthologue Defines Domains Conserved in EvolutionPMID 10196366Read ↗

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SMN deficiency alters Nrxn2 expression and splicing in zebrafish and mouse models of spinal muscular atrophySemantic proximity Read ↗

Specific interaction of Smn, the spinal muscular atrophy determining gene product, with hnRNP-R and gry-rbp/hnRNP-Q: a role for Smn in RNA processing in motor axons?Semantic proximity Read ↗

The survival motor neuron gene smn-1 interacts with the U2AF large subunit gene uaf-1 to regulate Caenorhabditis elegans lifespan and motor functions.Semantic proximity Read ↗

SMA-causing missense mutations in survival motor neuron (Smn) display a wide range of phenotypes when modeled in Drosophila.Semantic proximity Read ↗

Delivery of bifunctional RNAs that target an intronic repressor and increase SMN levels in an animal model of spinal muscular atrophySemantic proximity Read ↗

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Specific Sequences of the Sm and Sm-like (Lsm) Proteins Mediate Their Interaction with the Spinal Muscular Atrophy Disease Gene Product (SMN)Semantic proximity Read ↗

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