Article
Evidence for a polyclonal etiology of palmar fibromatosis.
The Journal of hand surgery - 1 Mar 1999
Chansky H A, Trumble T E, Conrad E U, Wolff J F, Murray L W, Raskind W H
Abstract excerpt
X chromosome inactivation patterns at the androgen receptor locus were evaluated to determine clonality in microdissected lesional tissue and in leukocytes from 2 women with Dupuytren's disease. The tissue from both patients generated a polyclonal pattern of X chromosome inactivation of the human androgen receptor gene. This finding supports a polyclonal reactive process as the underlying etiology for palmar...
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