Article
A model for the origins and spread of drug-resistant malaria.
Parasitology - 1 Aug 1997
Hastings I M
Abstract excerpt
A general method of investigating parasite population genetics is presented and used to investigate the evolution of drug resistance in Plasmodium. The most important biological factor is the nature of the control, presumably through host immunity, of the malarial infection. Two models are examined: a 'generalized immunity' (GI) model in which immunity regulates the overall level of infection, and a 'specific...
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