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Article

Preservation of duplicate genes by complementary, degenerative mutations.

Genetics - 1 Apr 1999

Force A, Lynch M, Pickett F B, Amores A, Yan Y L, Postlethwait J

Abstract excerpt

The origin of organismal complexity is generally thought to be tightly coupled to the evolution of new gene functions arising subsequent to gene duplication. Under the classical model for the evolution of duplicate genes, one member of the duplicated pair usually degenerates within a few million years by accumulating deleterious mutations, while the other duplicate retains the original function. This model...

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PMID: 10101175
DOI: 10.1093/genetics/151.4.1531
PMCID: PMC1460548

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