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Article

Effect of G40R mutation on the binding of human SRY protein to DNA: a molecular dynamics view.

Proteins - 1 Apr 1999

Tang Y, Nilsson L

Abstract excerpt

Molecular dynamics simulation was conducted to investigate the reason why the mutant G40R of hSRY protein has a low affinity for DNA. Compared with the previous dynamics results of the wild-type hSRY-HMG-DNA complex, the results of molecular dynamics simulation on the mutant G40R hSRY-HMG-DNA system demonstrated that the whole structure of DNA (especially the second strand) had a major deviation away from the...

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Source

Identifiers

PMID: 10090290
DOI: 10.1002/(sici)1097-0134(19990401)35:1<101::aid-prot10>3.0.co;2-5

Genes

SRY

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Effect of G40R mutation on the binding of human SRY protein to DNA: a molecular dynamics view.PMID 10090290Read ↗

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Structure-function relationships in human testis-determining factor SRY: an aromatic buttress underlies the specific DNA-bending surface of a high mobility group (HMG) box.Semantic proximity Read ↗

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