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Article

Natural history of colorectal cancer.

The American journal of medicine - 25 Jan 1999

Winawer S J

Abstract excerpt

Colorectal cancer arises from a precursor lesion, the adenomatous polyp, which forms in a field of epithelial cell hyperproliferation and crypt dysplasia. Progression from this precursor lesion to colorectal cancer is a multistep process, accompanied by alterations in several suppressor genes that result in abnormalities of cell regulation, and has a natural history of 10-15 years. Environmental factors and...

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Identifiers

PMID: 10089106
DOI: 10.1016/s0002-9343(98)00338-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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