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Identification and Characterization of thecpsLocus ofStreptococcus suisSerotype 2: the Capsule Protects against Phagocytosis and Is an Important Virulence Factor

1 Apr 1999

Abstract excerpt

To study the role of the capsule of Streptococcus suis serotype 2 in virulence, we generated two isogenic mutants disturbed in capsule production. For that purpose, we first cloned and characterized a major part of the capsular polysaccharide biosynthesis (cps) locus of S. suis serotype 2. Based on the established sequence, 14 open reading frames (ORFs), designated Orf2Z, Orf2Y, Orf2X, and Cps2A to Cps2K, were...

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PMID: 10085014
DOI: 10.1128/iai.67.4.1750-1756.1999

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