Article
Genotyping single nucleotide polymorphisms by primer extension and high performance liquid chromatography.
Human genetics - 1 Jan 1999
Hoogendoorn B, Owen M J, Oefner P J, Williams N, Austin J, O'Donovan M C
Abstract excerpt
We have investigated the possibility of genotyping single nucleotide polymorphisms (SNPs) by primer extension and high performance liquid chromatography (HPLC). Using three polymorphisms of current interest to our group (an A/G polymorphism in the proneurotensin gene and A/G and T/C polymorphisms in the 5HT2a receptor gene), we show that robust signal is obtained using this simple analytic method which has the...
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