Article
Effects of dystrophin isoforms on signal transduction through neural retina: genotype-phenotype analysis of duchenne muscular dystrophy mouse mutants.
Molecular genetics and metabolism - 1 Feb 1999
Pillers D A, Weleber R G, Green D G, Rash S M, Dally G Y, Howard P L, Powers M R, Hood D C, Chapman V M, Ray P N, Woodward W R
Abstract excerpt
Duchenne and Becker muscular dystrophy patients have mutations in the dystrophin gene. Most show reduced b-wave amplitudes in the dark-adapted electroretinogram (ERG). We studied normal C57BL/6J mice and five X-linked muscular dystrophy strains with different dystrophin mutations to determine whether the location of the mutation within the gene affects the mouse ERG and to correlate such effects with dystrophin...
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