Article
Angiopoietins 3 and 4: diverging gene counterparts in mice and humans.
Proceedings of the National Academy of Sciences of the United States of America - 2 Mar 1999
Valenzuela D M, Griffiths J A, Rojas J, Aldrich T H, Jones P F, Zhou H, McClain J, Copeland N G, Gilbert D J, Jenkins N A, Huang T, Papadopoulos N, Maisonpierre P C, Davis S, Yancopoulos G D
Abstract excerpt
The angiopoietins have recently joined the members of the vascular endothelial growth factor family as the only known growth factors largely specific for vascular endothelium. The angiopoietins include a naturally occurring agonist, angiopoietin-1, as well as a naturally occurring antagonist, angiopoietin-2, both of which act by means of the Tie2 receptor. We now report our attempts to use homology-based cloning...
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