Article
Low frequency of TEL-AML1 in relapsed acute lymphoblastic leukemia supports a favorable prognosis for this genetic subgroup.
Leukemia - 1 Jan 1999
Rubnitz J E, Behm F G, Wichlan D, Ryan C, Sandlund J T, Ribeiro R C, Rivera G K, Hancock M L, Relling M V, Evans W E, Pui C H, Downing J R
Abstract excerpt
The long-term outcome of children with TEL-AML1-positive acute lymphoblastic leukemia (ALL) is uncertain. Although studies of newly diagnosed cases have indicated that the TEL-AML1 fusion confers a favorable prognosis, analyses of relapsed cases have suggested that this may not be true. Because of treatment implications for this subgroup of patients, we have now analyzed 49 cases of relapsed ALL for the presence...
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