Article
SAA1 alleles as risk factors in reactive systemic AA amyloidosis.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis - 1 Dec 1998
Booth D R, Booth S E, Gillmore J D, Hawkins P N, Pepys M B
Abstract excerpt
SAA1 is the predominant isoform of acute phase human SAA deposited as AA amyloid fibrils in reactive systemic amyloidosis. It has recently been reported that in the Japanese population, in whom the SAA1 gamma allele occurs with a frequency of 37%, possession of, and especially, homozygosity for this allele is a significant risk factor for AA amyloidosis in adult patients with rheumatoid arthritis (RA). In...
Topics
- Adult
- Alleles
- Amyloidosis
- Base Sequence
- Case-Control Studies
- Cohort Studies
- DNA Primers
- Genotype
- Humans
- Male
- Risk Factors
- Serum Amyloid A Protein