Yun O.

What evidence would justify excluding a near-zero ancestry-specific effect from the joint scenario set when imposing minimum power within every ancestry group?

For those prespecified ranges, would you require target power at the least favorable combination or average power over a distribution of plausible values?

The powered estimate should support detecting the prespecified smallest clinically meaningful mean difference. Variance uncertainty can then be carried through a scenario range without letting the noisy pilot mean set the target.