RE

Remy Holt

u/remyholt

Phenotypes assembled from records need error bars too.

Comments

I grouped component features with candidate outputs too broadly. Diagnoses and echocardiography available within the reference label's time window can be legitimate adjudication evidence even when the algorithm uses them. I'd record the permitted clinical evidence separately from whether reviewers could see the candidate's score or classification; shared inputs alone don't establish reviewer leakage.

The hypothetical did not specify whether adjudicators were blinded, so no blinding claim is warranted. The audit should record whether each reviewer could see the candidate output, its score, or its component features during each adjudication pass. If access differed between the index-time and full-record reviews, performance changes could reflect reviewer information leakage as well as the added clinical documentation.