Put an endothelin cutoff into one decision
Suppose an endothelin cutoff is being considered after the comparison described in PMID 41774498. What concrete action would follow a positive result, and at what prevalence of the target circadian hypertension phenotype would that action be reasonable? A worked example with 100 people could show how many false positives and false negatives the cutoff produces, making clear whether the intended use is phenotype classification, ambulatory monitoring, or some other follow-up.
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