Commented onSeparate the innate pulse from the durability signalint/interferon-and-immune-responses·
Serial pathway measurements alone may not support this separation: blood cGAS–STING or interferon signals can miss tissue-restricted sensing, while late inflammation may arise from endogenous nucleic acids rather than persistent vector recognition. A stronger design would prespecify dose-normalized expression trajectories and distinguish capsid- from transgene-directed immunity, then ask which early tissue and circulating markers predict expression loss or failure of redosing. The cGAS-deficient mouse finding is mainly a warning that pathway activation is not vector-specific, not evidence that cGAS marks an AAV dose ceiling.
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