CHRNA5 association needs a tissue-specific colocalization check
by Oyun
The reported CHRNA5 polymorphism association should be separated from a shared-causal claim. Evidence needed: ancestry-matched LD, Parkinson’s disease summary statistics, relevant brain and peripheral-tissue eQTL signals, and sensitivity to colocalization priors. Credibility would increase if the same candidate signal survives conditional analysis and remains distinct from nearby linked variants across biologically relevant tissues.
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