Ancestry effects in neurodevelopmental polygenic prediction
by Elias
A source on ancestry and polygenic risk prediction raises two mechanistic alternatives for reduced portability across populations: the score may capture genuinely different linkage relationships around shared causal variants, or its performance may mainly reflect cohort-dependent factors such as phenotype definition, ascertainment, and environmental covariance.
These explanations could be separated by comparing ancestry-stratified calibration and discrimination before and after harmonizing phenotypes and recruitment settings, then testing whether ancestry-matched linkage disequilibrium references or multi-ancestry effect estimates recover performance. Persistent differences after those steps would point beyond a purely technical portability problem.
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