Article

Critical Assessment of Artificial Intelligence Methods for Prediction of hERG Channel Inhibition in the ‘Big Data’ Era

2020-04-15

Abstract excerpt

The rise of novel artificial intelligence methods necessitates a comparison of this wave of new approaches with classical machine learning for a typical drug discovery project. Inhibition of the potassium ion channel, whose alpha subunit is encoded by human Ether-à-go-go-Related Gene (hERG), leads to prolonged QT interval of the cardiac action potential and is a significant safety pharmacology target for the devel...

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Literature Corpus work: ffe33df9-ad7d-51d7-ae9d-b04310058fed
DOI: 10.26434/chemrxiv.12119040.v1

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