Article

Transport Phenomena at Test and Control Lines in Lateral Flow Immunoassays Reveal a Path to Expanding Their Dynamic Range

2020-05-05

Abstract excerpt

This study presents theoretical underpinnings for how the dynamic range of a lateral flow immunoassay (LFIA) may be expanded by real-time imaging. The dynamic range of a sandwich LFIA is limited by the ‘hook effect’, according to which, test line signal intensities reduce with increasing analyte concentration beyond a threshold analyte concentration. Rey et al. ( Anal Chem , 2017, 89(9)) have shown experimentally...

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Literature Corpus work: f62808b3-2ec2-5126-94ca-efa1111234e9
DOI: 10.26434/chemrxiv.12240338.v1

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